Antibody Optimization (ModiTune™)

Antibody chimerization

Our antibody sequencing, cloning, reformatting, and expression service can clone and express any variable antibody domain into any immunoglobulin context required, such as full size mouse, rabbit, chicken, human format,  chimeras with any Fc region of choice, including effector mutants or Fc fusions.

Antibody humanization

Animal-derived monoclonal antibodies can elicit human anti-animal antibody responses in patients. Therefore it is usually necessary to replace the animal content with the corresponding human amino acid residues. We provide a robust and efficient antibody humanization service, which consistently retains affinity and specificity levels. Our approach is based on state of the art in silico antibody modeling to identify essential framework and CDR residues for grafting onto a human antibody framework.

Antibody affinity maturation

Antibody affinity is important in therapeutic and diagnostic applications. ModiQuest’s antibody affinity maturation service can improve antibodies affinities by several fold. We can apply different strategies to increase the affinity of your antibody, including gene shuffling and random mutagenesis.

 

All our antibody development services are accessible on a fee-for-service (royalty-free) basis.  For more information about our antibody optimizaion capabilities, timing and pricing, please contact us.

 

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